Abstract (Krug et al., 2020 Molecular Autism, article # 54)
Advanced paternal age (APA) is a risk factor for several neurodevelopmental disorders, including autism and schizophrenia.... This study demonstrates associations between APA and social behaviors across species. They might be driven by changes in the expression of microRNAs and/or epigenetic changes regulating neuronal plasticity, leading to brain morphological changes and FRONTO-HYPOCAMPAL CONNECTIVITY, a network which has been implicated in social interaction.
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